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43 Cards in this Set

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What are the ssx of discoid LE?

1.  Above the neck
2.  Scaly, erythematous, atrophic plaques
3.  Scarring, atrophy, and pigment changes

1. Above the neck


2. Scaly, erythematous, atrophic plaques


3. Scarring, atrophy, and pigment changes

What are the ssx of subacute cutaneous LE?

1. Leukopenia


2. Arthralgia


3. Psoriasis-like polycyclic annular lesions


4. Shawl distribution

What antibodies are usually positive in SCLE?

1.  ANA
2.  Anti-Ro/SSA

1. ANA


2. Anti-Ro/SSA

What are the ssx of SLE?

1. Malar rash


2. 4/11 other criteria

For what type of lupus is ANA most sensitive?

1. SLE

How do you tx DLE, SCLE, and SLE?

1. Sunscreen


2. Hydroxychloroquine


3. Dapsone


4. Steroids

What are the ssx of morphea scleroderma?

1.  Rose or violaceous macules
2.  Become smooth, hard, depressed, and yellowish-white
3.  Common on trunk

1. Rose or violaceous macules


2. Become smooth, hard, depressed, and yellowish-white


3. Common on trunk

What are the ssx of linear scleroderma?

1.  Lesions that follow lines of Blaschko
2.  Parasagittal lesions on frontal scalp extend down onto forehead= En coupe de sabre

1. Lesions that follow lines of Blaschko


2. Parasagittal lesions on frontal scalp extend down onto forehead= En coupe de sabre

What are the ssx of CREST syndrome?

1. Calcinosis


2. Raynaud


3. Esophageal dysmotility


4. Sclerodactyly


5. Telangiectasias




Anti-centromere antibodies

What are the ssx of PSS?

1.  Raynaud
2.  Thickening of dermal collagen
3.  Fibrosis and vascular abnormalities of internal organs
4.  Sclerodactyly
5.  Digital pitting scars of fingertips

1. Raynaud


2. Thickening of dermal collagen


3. Fibrosis and vascular abnormalities of internal organs


4. Sclerodactyly


5. Digital pitting scars of fingertips

What is the major cause of death in PSS?

1. Pulmonary disease

What antibodies are positive in PSS?

1. Anti Scl-70---- anti-topoisomerase-1

How do you tx morphea?

1. Intralesional steroids

How do you tx Raynaud's?

1. CCB--- nifedipine


2. Avoid cold


3. Don't smoke

How do you tx PSS?

1. Cyclophosphamide helps


2. Phototx

What are the ssx of dermatomyositis?

1.  Heliotrope rash
2.  Gottron's papules
3.  Shawl sign--- telangiectasias of upper chest/shoulder
4.  Symmetrical proximal muscle weakness

1. Heliotrope rash


2. Gottron's papules


3. Shawl sign--- telangiectasias of upper chest/shoulder


4. Symmetrical proximal muscle weakness

What antibodies are associated with dermatomyositis?

1. Positive anti-Jo-1


2. Anti-Mi-2 for skin disease

How do you tx dermatomyositis?

1. Prednisone


2. Immunosuppressants


3. PT

What are the ssx of sarcoidosis?

1.  Systemic granulomatous disorder
2.  Erythema nodosum
3.  Lupus vernio
4.  Anterior uveitis

1. Systemic granulomatous disorder


2. Erythema nodosum


3. Lupus vernio


4. Anterior uveitis

What is the MC manifestation of sarcoidosis?

1. Lung disease---- potato nodes= bilateral hillier LAD

What are the ssx of Lofgren's syndrome?

1. Erythema nodosum


2. Bilateral hilar LAD


3. Polyarthralgias

How do you tx sarcoidosis?

1. Steroids


2. Hydroxychloroquine


What are the ssx of Peutz-Jegher syndrome?

1.  AD
2.  Perioral melanotic freckles
3.  GI polyps
4.  Abdominal pain

1. AD


2. Perioral melanotic freckles


3. GI polyps


4. Abdominal pain

What are the ssx of Gardner syndrome?

1. AD


2. Epidermal inclusion cysts, osteomas, lipomas, fibromas


3. Intestinal polyposis

How do you tx Gardner syndrome?

1. Total colectomy

What are the ssx of Osler-Weber-Rendu disease?

1.  Mat-like tufts of telangiectasias
2.  GI bleeding

1. Mat-like tufts of telangiectasias


2. GI bleeding


How do you tx Osler-Weber-Rendu disease?

1. Blood replacement


2. Fe supplementation

How do you differentiate CREST from Osler-Weber-Rendu disease?

1. No anti-centromere Abs

What are the ssx of IBD?

1. Aphthous ulcers during exacerbations


2. Polyarteritis nodosa


3. Pellagra


4. Pyoderma gangrenosum

What are the ssx of celiac disease?

1.  Dermatitis herpetiformis--- excoriations, pruritus

1. Dermatitis herpetiformis--- excoriations, pruritus

What are the ssx of porphyria cutanea tarda?

1.  Vesicles and bullae on sun-exposed areas
2.  Atrophic scarring
3.  Milia
4.  Facial hypertrichosis

1. Vesicles and bullae on sun-exposed areas


2. Atrophic scarring


3. Milia


4. Facial hypertrichosis

What are the ssx of liver cirrhosis?

1.  Spider angiomas
2.  Palmar erythema
3.  Jaundice
4.  Gynecomastia

1. Spider angiomas


2. Palmar erythema


3. Jaundice


4. Gynecomastia

What are the ssx of hypothyroidism?

1. Loss of lateral eyebrows


2. Cold, thick, dry skin

What are the ssx of hyperthyroidism?

1. Pretibial myxedema


2. Hyperhidrosis


3. Hair loss


4. Exophtalmos

What are the ssx of acanthuses nigricans?

1.  Velvety dark skin
2.  Adenocarcinoma of GI

1. Velvety dark skin


2. Adenocarcinoma of GI

What are the ssx of necrobiosis lipoidica diabeticorum?

1.  Red-yellow waxy atrophic plaques
2.  Due to microangiopathy

1. Red-yellow waxy atrophic plaques


2. Due to microangiopathy

How do you tx necrobiosis lipoidica diabeticorum?

1. Calcineurin inh


2. IL steroids


3. PUVA

What are the ssx of candidal intertrigo?

1.  Erythematous, well-demarcated lesions
2.  Tendency to fissure

1. Erythematous, well-demarcated lesions


2. Tendency to fissure

What are the ssx Cushing?

1. Central obesity


2. Striae


3. Hypertrichosis


4. Facial acne


5. Moon facies


6. Buffalo hump

What are the ssx of NF1?

1.  Cafe-au-lait macule
2.  Axillary/inguinal freckles=pathognomonic

1. Cafe-au-lait macule


2. Axillary/inguinal freckles=pathognomonic

What malignancies are associated with NF1?

1. CML


What are the ssx of Ehlers-Danlos syndrome?

1.  AD
2.  Bruising, rupture of blood vessels and viscera
3.  Thin, excessively stretchable skin
4.  AA subluxation

1. AD


2. Bruising, rupture of blood vessels and viscera


3. Thin, excessively stretchable skin


4. AA subluxation

What are the ssx of Marfan's syndrome?

1. Abnormal elastic tissue in fibrillin I and II


2. AAA, dissection


3. Striae


4. Herniations


5. Marfanoid habitus