Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/19

Click to flip

19 Cards in this Set

  • Front
  • Back
Drugs that inhibit folate manufacture of folate utilization?
ANTI-FOLATES
Drug used as part of the TX for toxolasmosis and alt. agent for prophylaxis of pneumocystis and toxoplasma?
Pyrimethamine
One of the DOC for TX and prophylaxis of pneumocystis?
Trimethoprim
DOC for the empiric therapy of UTIs in the outpatient population?
Trimethoprim and Sulfamethoxazole
Sulfa antibiotics (3)
sulfadiazine
sulfisoxazole
sulfamethoxazole
Those drugs that inhibit purine and pyrimidine synthesis indirectly by inhibiting folate manufacture cause what type of anemia?
Type of macrocytic anemia known as megaloblastic anemia
6-mercaptopurine is used in the treatment of which leukemia?
ALL ( acute lymphocytic leukemia )
6-mercaptopurine is converted to thio-IMP with which enzyme?
HGPRT
Drug that acts as a pyrimidine antagonist and used especially for non-lymphocytic leukemia?
Cytarabine
This inhibits thymidine synthesis?
Fluorouracil (5-FU)
Drugs discovered to be cytotoxic to human cells and therefore useful in the TX of CA?
antibiotic cytotoxins
At higher doses this drug inhibits DNA synthesis and at low doses it interferes with transcription?
Actinomycin D (dactinomycin)
This drug created radical oxygen species and decreases IP3 coupled transport processed?
Doxorubicin (adriamycin)
Cardiotoxic drug that can cause a cardiomyopathy resulting in heart failure?
Doxorubicin
This drug is nephrotoxic, hepatotoxic, toxic to skin, and has the ability to cause fibrosis of the lung?
Bleomycin
List the 4 Fluoroquinolones
ciprofloxacin, levofloxacin, moxifloxacin, and gemifloxacin
MOA of fluoroquinolones
inhbit bacterial DNA gyrase
These antibiotics are not approved in children <16 yo d/t risk of joint cartilage and caution must be taken in those >60 yo d/t increased risk for tendinopathy?
Fluoroquinolones
Fluoroquinolones have excellent action against Gram negative or Gram positive bacteria?
BOTH