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10 Cards in this Set

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Physiology of Cholesterol synthesis and transport

Steampunk station


Liver Station = Import/export lipoprotein transporters


Intestine Airbase = Small intestine site of absorption of FFA and cholesterol


Gold Bars = Cholesterol


Hot air balloon = Chylomicron


Chest = Cholesterol ester for cholesterol transfer (gold inside)


Tridents in hot air balloon = Chylomicron full of triglycerides


E-shaped flag = Apolipoprotein A-E


Lipo port lighthouse = lipoprotein lipase (LPL) gets some tridents


Empty CHylomicrons enter liver at LDL receptor at apo E


HMG Crude ore reducer = HMG CoA reductase = makes cholesterol


Evaluator = Mevalonic acid is first intermediate


VLDL ship with B anchor = HAs tridents and B shaped anchor (B100)


Low density ship = lose tridents and only contain chests


LDL ship uses B anchor to dock at liver


High densitity Submarine = HDL from Liver collect bars


Load catch platform = Lecithin (LCAT) place for placing gold into chests


Chest transfer = Under LDL has chest sent to liver from Load catch




Statins

Steam punk pirates


Knock over crude ore reducer = inhibit HMG CoA reductase


Statin punk = Threatens workers to pull in LDL causing increased LDL receptor expression on hepatocytes, clearing LDLs from circulation


Sinking LDL ship = Lowers LDL levels


Punk kicking trident = Lowers truglycerides mildly


Raised submarine = Slight increased HDL levels


Gold bar plundered = Hypercholesterolemia is treated (first line)


Angel = Improves chances of survival in Cardiovascular events (MOST EFFECTIVE)


Crown = Coronary vasodilation


Broken heart strings = statin therapy helps in MI events


Pirate eating candy = Helps lower MI chance in Diabetics


Clack paint stroke = Statins help stroke patients


Chrome Tank = Metabolized by cytomcome P450 (expect pravastin)

Statin side effects

Tarantula painted = ARe teratogenic


Bite of Crispy chicken = Statins can cause elevated CK (myopathy) in weeks-months


Raised LFT flag = Mild elevations in Liver function tests



Cholesterol and Bile

Seagalls are bile


Loading cholesterol with seagalls makes them water soluble


Swept up into liver station



Chol-drugs

Cho"lobster"amine fighting statin punk


Prevents return of bile acids and cholesterol into liver


DEcK -A = inhibits fat soluble vitamin absorbtion and statins


Clamping on pipes = can causes constipation and bloating


Empty gold stores = Signal to form own cholesterol activating HMG ore reducer and upregulating LDL receptors (B anchors)


Cho"lobster" Scaring tridents onto VLDL = INcreases blood VLDL and triglycerides


Seagall standing on stone = Can lead to gallstone formation

Ezetimibe

Z-Shaped eel


Blocking gold delivery at intestinal airbase from hot air balloon = blocks intestinal absorption of cholesterol by chylomicron


Sinking Ship = Decreaed LDL levels


Oily water = Diarrhea and constipation


Raised LFT flag = increased liver function tests



Evolocamab

Evoloctopus


Removing pesky-9-crabs which inhibit LDL workers = PCSK9 inhibitor


Increases uptake of LDL



Gemfibrozil (Fibratess)

Gem Jellyfish


Burning Newspaper - PPAR activated to upregulate LPL


Jellyfish take down Airship and LD ship = Lower VLDL and LDL


Escaping tridents = decrease serum triglycerides


Lifted Submarine = Raised HDL


elevated stain pirate eating crispy chicken = Statin + fibrates = myopathy and rhabdomyolysis


Seegalls on rocks = gallstone chance

Niacin

Loch Niacin monster


Vitamin B3


Elevated submarine = Most effective at increasing HDL


Nessie attacks airships, boats, tridents escape = Lowered VLDL, LDL and triglycerides


Red furnace = Cutaneous Flushing and warmth


Proslugger bat = increases prostaglandins


Fireextinguisher = NSAID inhibits flushing


Candy = Increase glucose


Knitting = Hyperuricemia


Raised LFT flag = increases Liver function tests. Hepatotoxicity



Fish Oil

Robotic fish


Sunken Trident = Lower triglycerides